The main objective of the Curtis Analytics is to help the food industry mitigate the acrylamide problem in food. Curtis Analytics is the fastest asparagine testing service company in the UK and hold contracts with five major bread and breakfast cereal producers, farmers and crisp producers. Curtis Analytics was established by Dr Tanya Curtis at the end of July 2017.
Formation of the company was encouraged by Rothamsted’s then head of Business Engagement and Commercialisation, Andrew Spencer. He believed that Curtis Analytics would be very successful, based on his previous experience with the similar spin-off and start-up businesses. The company started operating in 2017 and was entirely supported by Dr Tanya Curtis.
Tanya Curtis
Dr Curtis completed her PhD at Rothamsted Research as a postgraduate student registered in the Food Biosciences Department at Reading University. She continued investigations into acrylamide mitigation in wheat through her post-doctoral studies. Her BBSRC-funded £1.6M link project, BB/I020918/1, delivered 11 research papers in internationally reviewed journals and several invitations to International conferences. The last two papers provided bases for the agronomical improvement of wheat management for acrylamide reduction and mitigation that were incorporated into EU regulation: COMMISSION REGULATION (EU) 2017/2158 of 20 November 2017, establishing mitigation measures and benchmark levels for the reduction of the presence of acrylamide in food.
Sarah Usher
Dr Usher Completed her PhD in Epigenetics at Rothamsted Research in 2009. She has since worked as a post-doctoral scientist generating and characterising GM plants which produce beneficial oils. Dr Usher has extensive experience in molecular biology, biochemistry and analytical techniques, with over 18 years in the laboratory.
Ondrej Kosik
Ondrej is an experienced plant glycobiologist with a demonstrated history of working in the industry. His main interest is in plant cell wall architecture and its influence on human health and nutrition. Ondrej got his PhD in Biochemistry as part of Marie Currie training network. He held a postdoctoral position at Department of Biochemistry at University of Cambridge, followed by his second postdoc at Rothamsted Research. Ondrej is a specialist in method development, liquid chromatography, mass spectrometry, size-exclusion chromatography, glycobiology, enzymology and biotechnology. Ondrej joined Curtis Analytics in April 2019, bringing his expertise and passion for science.
Hiba Hassoun
Hiba is an experienced molecular biologist, passionate about science, with a BSc in Microbiology from University of Hertfordshire. After graduation, she worked at the Institute of Natural Sciences in Auckland, New Zealand, followed by a Scientist position at Molecular Diagnostic Company, Ely, Cambridge. She has experience in a medical microbiology lab, working for NHS as a biomedical support scientist. Hiba joined Curtis Analytics in April 2019, loving the new change of direction in her science career.
Featured Publications
Selected publications Tanya Curtis
Nigel G Halford, Tanya Y Curtis, Acrylamide in Food, World Scientific Europe Ltd (28 Feb. 2019).
Curtis, T; Halford, NG; Food security: the challenge of increasing wheat yield and the importance of not compromising food safety Annals of Applied Biology 164 3 354-372 2014 Blackwell Publishing Ltd Oxford, UK
Halford, NG; Curtis, TY; Muttucumaru, N; Postles, J; Mottram, DS; Sugars in crop plants Annals of Applied Biology 158 1 Jan-25 2011 Blackwell Publishing Ltd Oxford, UK
Halford, N G; Curtis, T Y; Muttucumaru, N; Postles, J; Elmore, JS; Mottram, DS; The acrylamide problem: a plant and agronomic science issue Journal of experimental botany 63 8 2841-2851 2012 Oxford University Press
Curtis, T Y; Muttucumaru, N; Shewry, PR; Parry, M AJ; Powers, S J; Elmore, JS; Mottram, DS; Hook, S; Halford, N G; Effects of genotype and environment on free amino acid levels in wheat grain: implications for acrylamide formation during processing Journal of agricultural and food chemistry 57 3 1013-1021 2009 American Chemical Society
Curtis, T Y; Powers, S J; Balagiannis, D; Elmore, JS; Mottram, DS; Parry, M AJ; Rakszegi, M; Bedo, Z; Shewry, P R; Halford, N G; Free amino acids and sugars in rye grain: implications for acrylamide formation Journal of Agricultural and Food Chemistry 58 3 1959-1969 2010 American Chemical Society
Muttucumaru, Nira; Elmore, J Stephen; Curtis, Tanya; Mottram, Donald S; Parry, Martin AJ; Halford, Nigel G; Reducing acrylamide precursors in raw materials derived from wheat and potato Journal of Agricultural and Food Chemistry 56 15 6167-6172 2008 ACS Publications
Halford, Nigel G; Curtis, Tanya Y; Chen, Zhiwei; Huang, Jianhua; Effects of abiotic stress and crop management on cereal grain composition: implications for food quality and safety Journal of Experimental Botany 66 5 1145-1156 2014 Oxford University Press UK
Halford, N G; Muttucumaru, N; Curtis, T Y; Parry, M AJ; Genetic and agronomic approaches to decreasing acrylamide precursors in crop plants Food additives and contaminants 24 sup1 26-36 2007 Taylor & Francis
Byrne, EH; Prosser, I; Muttucumaru, N; Curtis, T Y; Wingler, A; Powers, S; Halford, N G; Overexpression of GCN2‐type protein kinase in wheat has profound effects on free amino acid concentration and gene expression Plant biotechnology journal 10 3 328-340 2012 Blackwell Publishing Ltd Oxford, UK
CURTIS, TANYA; GENETIC AND ENVIRONMENTAL FACTORS CONTROLLING ACRYLAMIDE FORMATION IN WHEAT PRODUCTS 2010
Selected publications Sarah Usher
Rentel, M. C., Lecourieux, D., Ouaked, F., Usher, S. L., Petersen, L., Okamoto, H., Knight, H., Peck, S. C., Grierson, C. S., Hirt, H., Knight, M. R. (2004). OXI1 kinase is necessary for oxidative burst-mediated signalling in Arabidopsis. Nature 427:858-861
Betancor, M. B., Sprague, M., Usher, S., Sayanova, O., Campbell, P. J., Napier, J. A., Tocher, D. R. (2015). A nutritionally-enhanced oil from transgenic Camelina sativa effectively replaces fish oil as a source of eicosapentaenoic acid for fish. Scientific Reports: 5:8104. doi: 10.1038
Ruiz-Lopez, N., Haslam, R. P., Usher, S. L., Napier, J. A., Sayanova, O. (2013). Reconstitution of EPA and DHA biosynthesis in arabidopsis: iterative metabolic engineering for the synthesis of n-3 LC-PUFAs in transgenic plants. Metabolic Engineering; 17: 30-41
Betancor, M. B., Sprague, M., Sayanova, O., Usher, S., Campbell, P. J., Napier, J. A., Caballero, M. J., Tocher, D. R. (2015). Evaluation of a high-EPA oil from transgenic Camelina sativa in feeds for Atlantic salmon (Salmo salar L.): Effects on tissue fatty acid composition, histology and gene expression. Aquaculture; 444: 1-12.
Betancor MB, Li K, Bucerzan VS, Sprague M, Sayanova O, Usher S, Han L, Norambuena F, Torrissen O, Napier JA, Tocher DR, Olsen RE. (2018). Oil from transgenic Camelina sativa containing over 25 % n-3 long-chain PUFA as the major lipid source in feed for Atlantic salmon (Salmo salar). British Journal of Nutrition; 119(12):1378-1392
Usher, S., Haslam, R. P., Ruiz-Lopez, N., Sayanova, O., Napier, J. A. (2015). Field trial evaluation of the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Camelina sativa: Making fish oil substitutes in plants. Metabolic Engineering Communications; 2: 93-98
Napier, J. A., Usher, S., Haslam, R. P., Ruiz-Lopez, N., Sayanova, O. (2015). Transgenic plants as a sustainable, terrestrial source of fish oils. European Journal of Lipid Science and Technology; 117(9): 1317-1324.
Ruiz-Lopez, N., Usher, S., Sayanova, O. V., Napier, J. A., Haslam, R. P. (2014). Modifying the lipid content and composition of plant seeds: engineering the production of LC-PUFA. Applied Microbiology and Biotechnology; 99(1): 143-54
Ruiz-Lopez, N., Haslam, R. P., Usher, S., Napier, J.A., Sayanova, O. (2015). An alternative pathway for the effective production of the omega-3 long-chain polyunsaturates EPA and ETA in transgenic oilseeds. Plant Biotechnology Journal; 13(9):1264-75
PhD thesis: Nucleosome Positioning in Arabidopsis
Selected publications Delia Corol
JR Howarth, S Parmar, J Jones, CE Shepherd, DI Corol, AM Galster (2008). Co-ordinated expression of amino acid metabolism in response to N and S deficiency during wheat grain filling Journal of experimental botany 59 (13), 3675-3689
MJ Ebner, DI Corol, H Havlikova, JW Honour, JP Fry (2006). Identification of neuroactive steroids and their precursors and metabolites in adult male rat brain. Endocrinology 147 (1), 179-190
Laura Perez-Fons, Tom Wells, Delia I Corol, Jane L Ward, Christopher Gerrish, Michael H Beale, Graham B Seymour, Peter M Bramley, Paul D Fraser (2014). A genome-wide metabolomic resource for tomato fruit from Solanum pennellii Scientific reports 4, 3859
Delia-Irina Corol, Catherine Ravel, Mariann Raksegi, Zoltan Bedo, Gilles Charmet, Michael H Beale, Peter R Shewry, Jane L Ward (2012). Effects of genotype and environment on the contents of betaine, choline, and trigonelline in cereal grains Journal of agricultural and food chemistry 60 (21), 5471-5481
IM Scott, CP Vermeer, M Liakata, DI Corol, JL Ward, W Lin, HE Johnson, …(2010). Enhancement of plant metabolite fingerprinting by machine learning Plant physiology 153 (4), 1506-1520
IM Scott, W Lin, M Liakata, JE Wood, CP Vermeer, D Allaway, JL Ward, John Draper, MH Beale, DI Corol, JM Baker, Ross Donald King (2013). Merits of random forests emerge in evaluation of chemometric classifiers by external validation Analytica chimica acta 801, 22-33
O Ghannoum, MJ Paul, JL Ward, MH Beale, DI Corol, JP Conroy (2008). The sensitivity of photosynthesis to phosphorus deficiency differs between C3 and C4 tropical grasses Functional Plant Biology 35 (3), 213-221
N Toma, L Ghetea, R Nitu, DI Corol (2001). Progress and perspectives in the biotechnology of lichens Romanian Biotechnological Letters 6, 1-16.
MZ Qaiser, DEM Dolman, DJ Begley, NJ Abbott, M Cazacu‐Davidescu, …(2017). Uptake and metabolism of sulphated steroids by the blood–brain barrier in the adult male rat Journal of neurochemistry 142 (5), 672-685
D Corol, C Harflett, M Beale, J Ward (2014). An efficient high throughput metabotyping platform for screening of biomass willows. Metabolites 4 (4), 946-976
Selected publications Ondrej Kosik
Cabib E., Farkas V., Kosik O., Blanco N., Arroyo J., McPhie P. (2008) Assembly of the yeast cell wall: Crh1p and Crh2p act as transglycosylases in vivo and in vitro. Journal of Biological Chemistry 283(44), 29859-29872.
Derba-Maceluch M., Awano T., Takahashi J., Lucenius J., Ratke C., Kontro I., Busse-Wicher M., Kosik O., Tanaka R., Winzell A., Kallas A., Lesniewska J., Berthold F., Immerzeel P., Teeri T.T., Ezcurra I., Dupree P., Serimaa R. Mellerowicz E.J. (2015) Suppression of xylan endotransglycosylase PtxtXyn10A affects cellulose microfibril angle in secondary wall in aspen wood. New Phytologist 205(2), 666-681.
Kosik O., Auburn R.P., Russell S., Stratilova E., Garajova S., Hrmova M., Farkas V. (2008) Polysaccharide microarrays for high-throughput screening of transglycosylase activities in plant extracts. Glycoconjugate Journal 27(1), 79-87.
Chatzifragkou A., Kosik O., Prabhakumari P.C.; Lovegrove A., Frazier R.A., Shewry P.R., Charalampopoulos D. (2015) Biorefinery strategies for upgrading Distillers’ Dried Grains with Solubles (DDGS). 50(12), 2194-2207.
Kosik O. and Farkas V. (2008) One-pot fluorescent labeling of xyloglucan oligosaccharides with sulforhodamine. Analytical Biochemistry 375(2), 232-236.
Ho A.L., Kosik O., Lovegrove A., Charalampopoulos D., Rastall R.A. (2018) In vitro fermentability of xylo-oligosaccharide and xylo-polysaccharide fractions with different molecular weights by human faecal bacteria. Carbohydrate Polymers 179, 50-58.
Zielke C., Kosik O., Ainalem M-L., Lovegrove A., Stradner A., Nilsson L. (2017) Characterization of cereal β-glucan extracts from oat and barley and quantification of proteinaceous matter. PLOS One 12(2), e0172034.
Chatzifragkou A., Prabhakumari P.C.; Kosik O., Lovegrove A., Shewry P.R., Charalampopoulos D. (2016) Extractability and characteristics of proteins deriving from wheat DDGS. Food Chemistry 198, 12-19.
De Santis M.A., Kosik O., Passmore D., Flagella Z., Shewry P.R., Lovegrove A. (2018) Comparison of the dietary fibre composition of old and modern durum wheat (Triticum turgidum spp. durum) genotypes. Food Chemistry, 244, 304-310.
Freeman J., Ward J.L., Kosik O., Lovegrove A., Wilkinson M.D., Shewry P.R., Mitchell R.A.C. (2017) Feruloylation and structure of arabinoxylan in wheat endosperm cell walls from RNAi lines with suppression of genes responsible for backbone synthesis and decoration. Plant Biotechnology Journal 15(11), 1429-1438.
The primary objective of the company is to help the food industry mitigate the
acrylamide problem in food. Curtis Analytics Ltd is the fastest asparagine testing service company in the UK with contracts from five major bread and breakfast cereal producers, farmers and crisp producers. Curtis Analytics Ltd (CAL) was established by Dr Tanya Curtis at the end of July 2017.
During the first year of its establishment Curtis Analytics successfully:
- Lead Innovate UK application for ASNInsta testing.
- Won a private supported project that aims to develop edible protein film for cereal and protein bars.
- Processed successfully 5000 samples in the first year of trading.
Important Information
Telephone: 01582 320980
